International journal of radiation biology
-
Int. J. Radiat. Biol. · May 2012
Randomized Controlled TrialEffect of local exposure to inhomogeneous static magnetic field on stomatological pain sensation - a double-blind, randomized, placebo-controlled study.
Static magnetic field (SMF) exposure was shown experimentally to beneficially affect the healing process. The aim of this randomized, controlled trial was to evaluate the pain-inhibitory effect of local exposure to SMF on temporomandibular disorders, on alveolitis and on aphta in the oral mucosa. ⋯ SMF exposure as a drug-free, fast and easy to use method could potentially help stomatologists, who seek for alternative methods of local anesthesia, especially when systemic anesthesia is contraindicated.
-
Int. J. Radiat. Biol. · Oct 2010
Prophylactic feeding with immune-enhanced diet ameliorates chemoradiation-induced gastrointestinal injury in rats.
To investigate the protective effect of immune-enhanced diet (IED) on chemoradiation-induced injury of the gastrointestinal mucosa. ⋯ Prophylactic feeding of IED has a protective effect on chemoradiation-induced gastrointestinal injury, which appears to involve the eradication of bacterial overgrowth.
-
Int. J. Radiat. Biol. · Feb 2010
Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain.
Pro-inflammatory environments in the brain have been implicated in the onset and progression of neurological disorders. In the present study, we investigate the hypothesis that brain irradiation induces regionally specific alterations in cytokine gene and protein expression. ⋯ The present study demonstrated that whole brain irradiation induces regionally specific pro-inflammatory environments through activation of AP-1, NF-kappaB, and CREB and overexpression of TNF-alpha, IL-1beta, and MCP-1 in rat brain and may contribute to unique pathways for the radiation-induced impairments in tissue function.
-
Int. J. Radiat. Biol. · Jul 2008
Effects of exposure to 50 Hz electric field at different strengths on oxidative stress and antioxidant enzyme activities in the brain tissue of guinea pigs.
The aim of this study was to evaluate the possible effects of varied exposure to 50 Hz extremely low frequency (ELF) electric field (EF) on the lipid peroxidation levels and antioxidant enzyme activities in the brain homogenates of guinea pigs. Subjects were exposed to 2 kV/m, 2.5 kV/m, 3 kV/m, 3.5 kV/m, 4 kV/m, 4.5 kV/m and 5 kV/m electric fields for three days, 8 h a day in both vertical and horizontal directions. ⋯ The present study observed effects of 50 Hz EF exposure on lipid peroxidation levels and antioxidant defense mechanisms but these were not statistically significant at the 95% confidence level. Further research on the effects ELF-EF exposure on lipid peroxidation levels and antioxidant defence mechanisms are warranted.
-
Int. J. Radiat. Biol. · Jun 2008
In vitro determination of radiation sensitivity parameters for DU-145 prostate cancer cells.
The prolonged delivery times associated with intensity modulated radiation therapy (IMRT) may reduce treatment effectiveness of radiation therapy for cancers with short repair half-times. In this study, in vitro radiation experiments with DU-145 prostate cancer cells were designed to quantify the half-time of sublethal damage repair. ⋯ The reported radiosensitivity parameters (alpha and alpha/beta) are larger than those derived from other in vitro experiments and clinical data. In contrast, the half-time for sublethal damage repair ( approximately 23 min) is close to the one derived from clinical data ( approximately 16 min). For such short repair half-times, the effectiveness of IMRT treatments may be substantially improved by decreasing the fraction delivery time.