International journal of radiation biology
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Int. J. Radiat. Biol. · Oct 2018
Clinical TrialEffect of acute exposure to radiofrequency electromagnetic fields emitted by a mobile phone (GSM 900 MHz) on electrodermal responsiveness in healthy human.
The present study aimed to determine the effect of acute exposure to electromagnetic fields (EMF) emitted by a mobile phone on electrodermal activity (EDA) in response to an auditory stimulus. ⋯ Our results showed a decrease in the number of responses and their amplitude as a result of placement of the mobile device and whether it was turned 'on' or 'off', but there were no changes associated with exposure to GSM radiofrequency waves in this group of volunteers.
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Int. J. Radiat. Biol. · Mar 2017
Development of a combined radiation and full thickness burn injury minipig model to study the effects of uncultured adipose-derived regenerative cell therapy in wound healing.
To develop an approach that models the cutaneous healing that occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of the effects of an autologous cell therapy on wound healing on thermal burn injury with concomitant radiation exposure was used to validate the utility of the model. ⋯ Although preliminary, this study provides a reproducible minipig model of thermal burn injury complicated by myelosuppressive total body irradiation that utilizes standardized procedures to evaluate novel countermeasures for potential use following attack by an improvised nuclear device.
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Int. J. Radiat. Biol. · Jul 2015
Ionizing radiation induces neuronal differentiation of Neuro-2a cells via PI3-kinase and p53-dependent pathways.
The influence of ionizing radiation (IR) on neuronal differentiation is not well defined. In this study, we investigated the effects of IR on the differentiation of Neuro-2a mouse neuroblastoma cells and the involvement of tumor protein 53 (p53) and mitogen-activated protein kinases (MAPK) during this process. ⋯ These results suggest that IR is able to trigger the neuronal differentiation of Neuro-2a cells and the activation of p53 via PI3K is an important step for the IR-induced differentiation of Neuro-2a cells.
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Int. J. Radiat. Biol. · Jan 2015
Potential implications of the bystander effect on TCP and EUD when considering target volume dose heterogeneity.
In light of in vitro evidence suggesting that radiation-induced bystander effects may enhance non-local cell killing, there is potential for impact on radiotherapy treatment planning paradigms such as the goal of delivering a uniform dose throughout the clinical target volume (CTV). This work applies a bystander effect model to calculate equivalent uniform dose (EUD) and tumor control probability (TCP) for external beam prostate treatment and compares the results with a more common model where local response is dictated exclusively by local absorbed dose. The broad assumptions applied in the bystander effect model are intended to place an upper limit on the extent of the results in a clinical context. ⋯ In terms of EUD and TCP, the bystander model demonstrates the potential to deviate from the common local LQ model predictions as dose heterogeneity through a prostate CTV varies. The results suggest, at least in a limiting sense, the potential for allowing some degree of dose heterogeneity within a CTV, although further investigation of the assumptions of the bystander model are warranted.
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Int. J. Radiat. Biol. · Nov 2014
Worker doses and potential health effects resulting from the accident at the Fukushima nuclear power plant in 2011.
The reliability of exposure scenarios used in the World Health Organization's Health Risk Assessment (HRA) for Fukushima workers was examined. HRA risk estimates for cancer incidence in these workers were then reviewed. ⋯ For the highest dose scenario (Scenario 4: 13 workers), LAR values for thyroid cancer up to 3.5% were estimated, but a radiation-related increase in thyroid cancer incidence is unlikely to be observed because of the small number of workers. For the two intermediate dose scenarios, a small number of cancer cases may occur, but these are unlikely to be observed because the variability in baseline rates of cancer incidence is much larger than the predicted radiation-related incidence rates.