Journal of investigative surgery : the official journal of the Academy of Surgical Research
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Biography Historical Article
Birth of scientific surgery. John Hunter versus Joseph Lister as the father or founder of scientific surgery.
John Hunter (1728-1793) has frequently been considered the "Father or Founder of Scientific Surgery". His inscription at Westminster Abbey presents him as "a gifted interpreter of the Divine Power and wisdom at work in the laws of organic life and the Founder of Scientific Surgery." I take issue with Hunter being considered the father or founder of scientific surgery and propose Joseph Lister (1827-1912) as the one who should receive this consideration. Hunter was a skilled surgeon, an inquisitive innovator, keen observer, great naturalist, and astute thinker, who made no surgical discoveries of any transcendence to the discipline. ⋯ Therefore, he should not be considered the "Father or Founder of Scientific Surgery." On the contrary, Lister became a revolutionary scientific innovator by explaining the pervasive role of microorganisms in surgical wounds. His work directly affected surgery and its role in medicine. Lister, therefore, should be considered the "Father or Founder of Scientific Surgery."
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Resveratrol (RSV) is a natural polyphenolic compound found in grape skins and the red wine which improves histological reorganization of the regenerating tissue in dermal wound healing. Since anastomotic healing possesses paramount importance to prevent complications in colorectal surgery, the present study is aimed to evaluate the effect of RSV on the healing of experimental left colonic anastomoses. ⋯ The study results suggest that exogenous RSV administration exerts a positive effect on experimental colonic wound healing in the rat. Although the precise cellular mechanisms by which RSV enhances anastomotic wound healing is not clear, stimulation of neovascularization, generation of collagen synthesis, inhibition of over inflammation, and restriction of oxidative injury seems to be of paramount importance.
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Randomized Controlled Trial
Ventilation during cardiopulmonary bypass: impact on neutrophil activation and pulmonary sequestration.
Cardiopulmonary bypass (CPB) is associated with neutrophil activation, pulmonary sequestration, and release of inflammatory mediators leading to pulmonary dysfunction. We investigate the effect of continuous ventilation during cardiopulmonary bypass on neutrophil activation and pulmonary sequestration. ⋯ Cardiopulmonary bypass during coronary artery bypass grafting is associated with increased neutrophil pulmonary sequestration, and blood neutrophil CD11b activation. Continuous ventilation during cardiopulmonary bypass does not significantly reduce neutrophil pulmonary sequestration or activation.
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Comparative Study
Improvement of the tissue-adhesive and sealing effect of fibrin sealant using polyglycolic acid felt.
Although fibrin sealant (FS) has an advantage of high biocompatibility, its adhesive force and sealing effect have been generally considered to be inadequate. In the present study, a high adhesive force and sealing effect were obtained by first rubbing fibrinogen solution into the target tissue, attaching polyglycolic acid (PGA) felt to the treated area, and finally spraying it with FS. This method was compared with three conventional FS application methods and a method using fibrin glue-coated collagen fleece. ⋯ The high adhesive force of FS with PGA felt seemed to be due the high fibrin content of the fibrin gel (FG). Light and electron microscopic observations suggested that the formation of FG in closer contact with the muscle fibers was a factor contributing to this superior adhesive force. Comparison of the sealing effect of the present method with other methods using various biomaterials in combination with FS showed that the sealing effect of FS with PGA felt was 1.4 times higher that of polyglactin 910, 1.8 times that of polytetrafluoroethylene, and 6.7 times that of oxidized regenerated cellulose.