Journal of clinical anesthesia
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Randomized Controlled Trial Clinical Trial
Effects of nilvadipine on the cardiovascular responses to tracheal intubation.
To evaluate the efficacy of nilvadipine given orally in attenuating the hypertensive response to laryngoscopy and intubation. ⋯ Oral administration of nilvadipine before induction of anesthesia is a simple and practical method for attenuating pressor response to laryngoscopy and tracheal intubation after standard elective induction under additional 1% enflurane-N2O anesthesia.
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Randomized Controlled Trial Clinical Trial
Partial attenuation of the cardiovascular responses to tracheal intubation with oral nisoldipine.
To evaluate the efficacy and safety of nisoldipine given orally in attenuating the cardiovascular responses to laryngoscopy and tracheal intubation. ⋯ Oral administration of nisoldipine before induction of anesthesia is a simple, practical, and safe method for attenuating pressor response to laryngoscopy and tracheal intubation.
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Randomized Controlled Trial Clinical Trial
Effect of esmolol on hemodynamics and intraocular pressure response to succinylcholine and intubation following low-dose alfentanil premedication.
To determine the effectiveness of esmolol hydrochloride (Brevibloc) as an additional adjunct to low-dose alfentanil premedication in controlling the hemodynamic response [heart rate (HR), mean arterial pressure (MAP), and intraocular pressure (IOP)] to succinylcholine and endotracheal intubation. ⋯ In an eye patient with coronary artery disease, or in any patient in whom tachycardia may be detrimental, esmolol may be a useful adjunct in combination with low-dose alfentanil to attenuate the increase in HR due to laryngoscopy and endotracheal intubation.
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Randomized Controlled Trial Clinical Trial
The efficacy of intramuscular ketorolac in combination with intravenous PCA morphine for postoperative pain relief.
To examine the efficacy of intramuscular (IM) ketorolac used in combination with intravenous (IV) patient-controlled analgesia (PCA) morphine for postoperative pain relief following intra-abdominal gynecologic surgery. ⋯ IM ketorolac significantly decreased PCA morphine requirements. The analgesic effects of the two drugs appear to be additive.
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Randomized Controlled Trial Clinical Trial
Fentanyl-induced muscle rigidity as affected by pretreatment with amantadine hydrochloride.
To determine whether the degree of muscle rigidity in humans caused by the administration of high-dose fentanyl is affected by pretreatment with amantadine hydrochloride, a drug that stimulates the release of dopamine in the basal ganglia. ⋯ Muscle rigidity associated with the administration of high-dose fentanyl is not attenuated by prior administration of amantadine in the dose range studied.