Journal of clinical anesthesia
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Randomized Controlled Trial Comparative Study
Systemic lidocaine decreases the Bispectral Index in the presence of midazolam, but not its absence.
To evaluate the effects of intravenous (IV) lidocaine on the Bispectral Index (BIS) in the presence or absence of midazolam. ⋯ IV lidocaine decreases BIS in the presence of midazolam, suggesting that the effect of lidocaine on BIS is not direct, but rather results from modulation by midazolam.