Journal of clinical anesthesia
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To evaluate factors affecting variability in response to remimazolam in general anesthesia. ⋯ If using a weight-based regimen, results illustrated an appropriate regimen of remimazolam for general anesthesia and post-surgical sedation in general and sensitive populations, although lower doses can be considered in elderly patients with a significant disease burden or in ASA Class 3 patients. The time-dependent change in clearance is not clinically relevant for up to 24 h.
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Multicenter Study Observational Study
The incidence of intraoperative hypotension in moderate to high risk patients undergoing non-cardiac surgery: A retrospective multicenter observational analysis.
Intraoperative hypotension is associated with perioperative morbidity. We undertook this project to describe the incidence of hypotension (defined as mean arterial pressure <65 mmHg). ⋯ There continues to be a significant burden of hypotension (defined as MAP <65 mmHg) across our multicenter cohort of hospitals.