Journal of clinical anesthesia
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Outpatient general anesthesia: a comparison of a combination of midazolam plus propofol and propofol alone.
To compare the hemodynamics, efficacy, safety, and postoperative recovery of patients following the use of either midazolam plus propofol or placebo plus propofol for induction and maintenance of general anesthesia for outpatient surgical procedures of less than two hours' duration. ⋯ Concomitantly administered midazolam and reduction-concentration propofol did not exacerbate the well-described hypotensive effects of full-strength propofol during induction of anesthesia. The time to intubation was equivalent with the combination of midazolam/propofol as compared with propofol alone. Recovery from the two regimens was not significantly different. However, reduced recall of perioperative events was observed more often in the midazolam/propofol regimen compared with propofol alone.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effects of intravenous and oral clonidine on hemodynamic and plasma-catecholamine response due to endotracheal intubation.
To investigate the effects of intravenous (IV) versus oral clonidine on alterations of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), and plasma-catecholamines due to endotracheal intubation. ⋯ In conclusion, IV clonidine reduced stress response to endotracheal intubation compared with placebo. Oral clonidine at the dose used was less effective in blunting hemodynamic stress response than IV clonidine.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Etomidate and thiopental-based anesthetic induction: comparisons between different titrated levels of electrophysiologic cortical depression and response to laryngoscopy.
To determine whether etomidate-based induction can provide better hemodynamics than a standard thiopental sodium-based anesthetic induction. ⋯ Etomidate-based anesthetic induction, titrated to EEG burst suppression, produced stable hemodynamics during laryngoscopy and intubation as compared with lower dose, more "classic" inductions with etomidate or thiopental.
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Randomized Controlled Trial Comparative Study Clinical Trial
Removal of the laryngeal mask airway in children: deep anesthesia versus awake.
To compare the incidence of adverse airway events identified with removal of the laryngeal mask airway (LMA) from an awake child or from a child before his or her airway reflexes had returned. ⋯ Removal of the LMA during anesthesia and after return of airway reflexes results in a similar incidence of airway problems in children.
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Randomized Controlled Trial Comparative Study Clinical Trial
Postoperative analgesia using a low-dose, oral-transdermal clonidine combination: lack of clinical efficacy.
To determine if a lower than previously reported oral-transdermal clonidine regimen could reduce postoperative morphine requirements without producing systemic side effects. ⋯ The low-dose oral-transdermal clonidine regimen evaluated failed to reduce postoperative morphine requirements, although patients who received clonidine were still at risk for developing hypotension.