Journal of biomaterials applications
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Currently a wide variety of polymer materials are being applied to fabricate nerve guide tubes to repair injured peripheral nerves. In this study we have examined whether collagen-chitosan nerve guides promotes nerve repair compared to chitosan nerve guides using histological analysis. ⋯ Collagen-chitosan guides improved axonal maturation measured by a significant increase in axon diameter and axon area. These findings indicate that the collagen-chitosan nerve guides can be applied to repair severed peripheral nerve ends.