BMJ : British medical journal
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Randomized Controlled Trial
Strategy for intention to treat analysis in randomised trials with missing outcome data.
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To provide information on the frequency and reasons for outcome reporting bias in clinical trials. ⋯ The prevalence of incomplete outcome reporting is high. Trialists seemed generally unaware of the implications for the evidence base of not reporting all outcomes and protocol changes. A general lack of consensus regarding the choice of outcomes in particular clinical settings was evident and affects trial design, conduct, analysis, and reporting.
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To determine the association of resting echocardiography before elective intermediate to high risk non-cardiac surgery with survival and length of hospital stay. ⋯ Preoperative echocardiography was not associated with improved survival or shorter hospital stay after major non-cardiac surgery. These findings highlight the need for further research to guide better use of this common preoperative test.
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To evaluate the association of overall and specific headaches with volume of white matter hyperintensities, brain infarcts, and cognition. ⋯ In this population based study, any history of severe headache was associated with an increased volume of white matter hyperintensities. Migraine with aura was the only headache type associated with brain infarcts. Evidence that headache of any type by itself or in combination with brain lesions was associated with cognitive impairment was lacking.