Journal of internal medicine
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Randomized Controlled Trial Clinical Trial
Insulin-like growth factor-I lowers fasting and postprandial triglyceride levels without affecting chylomicron clearance in healthy men.
To study whether IGF-I treatment alters the postprandial lipid and lipoprotein metabolism. ⋯ IGF-I treatment reduces the triglyceride levels most probably by decreasing insulin secretion and the production of VLDL particles, and possibly by increasing their turnover. IGF-I treatment has no significant effect on the metabolism of intestine-derived triglyceride-rich lipoproteins after a high fat meal in healthy young men.