Journal of internal medicine
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Multicenter Study
The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients.
To determine the contribution of classical risk factors to the development of cardiovascular disease (CVD) in patients with heterozygous familial hypercholesterolaemia (FH). ⋯ Male gender, smoking, hypertension, diabetes mellitus, HDL cholesterol and lipoprotein(a) levels proved to be important risk factors for CVD in FH patients. In addition to the routine institution of statin therapy, controlling these factors needs special attention in the management of this disorder.