Journal of internal medicine
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Multicenter Study
Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.
Nonalcoholic fatty liver disease is epidemiologically associated with hepatic and metabolic disorders. The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance. ⋯ These data suggest that long-term hepatic fat accumulation plays a causal role in the development of chronic liver disease.
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Multicenter Study Comparative Study
Distinct factors determine the kinetics of disease relapse in adults transplanted for acute myeloid leukaemia.
Disease recurrence remains the major cause of death in adults with acute myeloid leukaemia (AML) treated using either intensive chemotherapy (IC) or allogenic stem cell transplantation (allo-SCT). ⋯ Taken together, these data provide novel insights into the biology of disease recurrence after both allo-SCT and IC and have the potential to inform the design of novel maintenance strategies in both clinical settings.