Journal of anesthesia
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Journal of anesthesia · Jun 1998
Effect of anesthetics on the self-sustained oscillation in an artificial membrane induced by repetitive conformational change of DOPH molecules between hydrophilic and hydrophobic phases.
The mechanism of anesthesia was approached from a study of an artificial excitable membrane that well reproduced the active electrical properties of the nerve membrane. ⋯ The volatile anesthetic agents affected the hydrophobic oil droplets of the DOPH molecules and impeded their repetitive conformational change between the hydrophilic and hydrophobic phases, just as local anesthetics had been reported to do.
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Journal of anesthesia · Jun 1998
Effects of KRN2391-induced hypotension on the endocrine system and carbohydrate metabolism in halothane-anesthetized dogs.
The hemodynamic profiles of KRN2391-induced hypotension have been reported to be a hyperdynamic state. However, the endocrine effects of KRN2391-induced hypotension remain to be elucidated. We investigated the endocrine and metabolic effects of KRN2391-induced hypotension on the plasma concentrations of catecholamines, aldosterone, cortisol, glucose, and lactic acid and on plasma renin activity. ⋯ KRN2391-induced hypotension activates the sympathetic nervous system and consequently may modulate the renin-angiotensin-aldosterone axis and carbohydrate metabolism.
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Journal of anesthesia · Jun 1998
Comparative evaluation of TIVA with propofol-fentanyl and thiopental-sevoflurane anesthesia using laryngeal mask airway for diagnostic bronchoscopy.
Diagnostic bronchoscopy is performed under general anesthesia in our hospital. This study was designed to determine whether total intravenous anesthesia (TIVA) with propofol-fentanyl provides more stable hemodynamics using a laryngeal mask airway (LMA) for diagnostic bronchoscopy than thiopental-sevoflurane anesthesia. ⋯ TIVA with propofol-fentanyl in conjunction with an LMA performs better than thiopental-sevoflurane anesthesia for diagnostic bronchoscopy because of its superior maintenance of cardiovascular stability.
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Journal of anesthesia · Jun 1998
Muscle lactate concentration during experimental hemorrhagic shock.
Blood lactate concentration does not correspond well to oxygen transport variables during circulatory shock. Prolonged washout of lactate from tissues during shock has been reported. This study was designed to test the hypothesis that the discrepancy between serum lactate and oxygen metabolism is caused by the failure of lactate to wash out from the tissues and that tissue lactate may reflect the oxygen metabolism better. ⋯ In the setting of experimental hemorrhagic shock, only tissue lactate levels reflected the true deficit in oxygen metabolism. The difference between lactate levels in muscle and serum represented the severity of the shock.