Journal of anesthesia
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Journal of anesthesia · Jan 2007
The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia.
We previously found that propofol attenuated the mortality rate and inflammatory responses during endotoxemia in rats; however, whether propofol retains its antiinflammatory effects during hypothermia has not been determined. We investigated the effects of propofol on endotoxemic rats subjected to moderate or mild hypothermia. ⋯ During hypothermia, propofol administration does not have additive beneficial antiinflammatory effects.
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Journal of anesthesia · Jan 2007
Cardiac output increases the rate of carbon monoxide elimination in hyperpneic but not normally ventilated dogs.
The very high solubility of carbon monoxide (CO) in blood suggests that its elimination depends predominantly on ventilation and not perfusion. Nevertheless, hyperventilation is not used for CO elimination because of the adverse effects of hypocapnia. With isocapnic hyperpnea (IH), ventilation can be increased considerably without hypocapnia. This raises the issue of whether CO elimination is limited by perfusion during IH. We studied the effect of increasing cardiac output on t1/2, the half-time of decline of blood carboxyhemoglobin concentration ([COHb]), during normal ventilation (NV) and during IH. ⋯ These findings suggest that CO elimination during IH treatment is limited at least partly by pulmonary blood flow and may therefore be further augmented by increasing cardiac output.