Journal of anesthesia
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Journal of anesthesia · Apr 2014
Effects of morphine and fentanyl on 5-fluorouracil sensitivity in human colon cancer HCT116 cells.
Opioids are widely used for perioperative pain management in cancer surgery patients. It has been reported that opioids may alter cancer recurrence or progression; however, there are no published reports regarding the effects of opioids on chemotherapy after cancer surgery. Here we investigated the effects of opioids (morphine or fentanyl) on cell proliferation and 5-fluorouracil sensitivity in the human colon cancer cell line, HCT116. ⋯ Although fentanyl did not affect cell proliferation, morphine exposure for 6 h enhanced the proliferation. However, sensitivity of HCT116 cells to 5-fluorouracil was not altered in all treatment groups. The current study demonstrated that the opioids commonly used during postoperative periods do not affect 5-fluorouracil sensitivity in human colon cancer HCT116 cells.
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Journal of anesthesia · Apr 2014
Extent of sympathectomy affects postoperative compensatory sweating and satisfaction in patients with palmar hyperhidrosis.
Endoscopic thoracic sympathectomy (ETS) for the treatment of palmar hyperhidrosis is generally performed at one or two levels ranging between T2 and T4; however, compensatory sweating (CS) is an occasional bothersome side effect. The aim of our study was to evaluate the association between the extent of ETS and the degree of postoperative CS and palmar sweating, as well as patient satisfaction. ⋯ Compared to ETS at two levels, single-level ETS of T2 or T3 reduces postoperative palmar sweating to a milder degree, and causes CS to a less severe degree. The severity of CS is inversely correlated with the degree of patient satisfaction.
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Journal of anesthesia · Apr 2014
Letter Case ReportsPalatal perforation with McGrath Series 5 videolaryngoscope.
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Journal of anesthesia · Apr 2014
Letter Case ReportsUse of ROTEM and MEA in a cardiac surgical patient with ITP.