Journal of anesthesia
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Journal of anesthesia · Aug 2014
Case ReportsTreatment of life-threatening hypercapnia with isoflurane in an infant with status asthmaticus.
We encountered a 2-year-old child with life-threatening hypercapnia, with a PaCO(2) of 238 mm Hg and severe respiratory and metabolic acidosis, due to status asthmaticus that was refractory to steroid and bronchodilator therapy. Suspecting ventilatory failure and excessive ventilation-induced obstructive shock, we started respiratory physiotherapy in synchrony with her respiration, to facilitate exhalation from her over-inflated lungs. Isoflurane inhalation was commenced in preparation for extracorporeal circulation, to reduce the hypercapnia. ⋯ In our patient with a severe asthmatic attack, decreased exhalation secondary to asthma and overventilation during artificial ventilation resulted in overinflation of the lungs, which in turn led to cerebral edema and obstructive cardiac failure. The favorable outcome in this case was due to the short duration of hypercapnia. Hence, we conclude that the duration of hypercapnia is an important determinant of the morbidity and mortality of status asthmaticus-induced severe hypercapnia.
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Journal of anesthesia · Aug 2014
The role of electrical stimulation in ultrasound-guided subgluteal sciatic nerve block: a retrospective study on how response pattern and minimal evoked current affect the resultant blockade.
Nerve stimulation may be combined with ultrasound imaging for a block of deeply located nerves such as the sciatic nerve in the subgluteal region. At present, it is unknown how the use of nerve stimulation affects blockade after this nerve block. We retrospectively compared the effects of the two types of motor response and those of minimal evoked current above and below 0.5 mA on ultrasound-guided subgluteal sciatic nerve block using mepivacaine or ropivacaine, two local anesthetics with different onset time and duration. ⋯ When ultrasound-guided subgluteal sciatic nerve block was conducted with nerve stimulation, the motor response pattern did not markedly affect the progress of sensory or motor blockade or block duration. Lower minimal evoked current was associated with faster onset in sensory and motor block and longer block duration after mepivacaine and faster onset in motor block after ropivacaine. The clinical significance of this, however, has yet to be determined.
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Journal of anesthesia · Aug 2014
Letter Case ReportsIntracardiac mass of the LAA during CPB for MVR.
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Journal of anesthesia · Aug 2014
Sevoflurane induces cardioprotection through reactive oxygen species-mediated upregulation of autophagy in isolated guinea pig hearts.
Sevoflurane increases reactive oxygen species (ROS), which mediate cardioprotection against myocardial ischemia-reperfusion injury. Emerging evidence suggests that autophagy is involved in cardioprotection. We examined whether reactive oxygen species mediate sevoflurane preconditioning through autophagy. ⋯ Sevoflurane induces cardioprotection through ROS-mediated upregulation of autophagy.
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Journal of anesthesia · Aug 2014
The effects of stellate ganglion block on the electroencephalogram in rats.
It is reported that the sympathetic nervous system may play an important role in the arousal response. The present study evaluated the effect of stellate ganglion block (SGB) on electroencephalogram (EEG) activity in rats. ⋯ SGB with 0.2 ml 0.25 % bupivacaine significantly decreased EEG activities in rats. These results suggest that SGB can induce a sedative effect in rats. Further studies are required to investigate the behavioral tests for sedative effects of SGB.