Journal of anesthesia
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Journal of anesthesia · Jun 2020
Observational StudyPrediction of failed facemask ventilation: new scoring system for difficult airway.
We previously have shown that there was a strong correlation between failed facemask ventilation, failed ventilation through a supraglottic airway, and difficult tracheal intubation. The primary aim of this study was to evaluate whether or not an established method to predict difficult ventilation through a supraglottic airway was also useful for predicting failed facemask ventilation. ⋯ The predictive score for difficult ventilation through a supraglottic airway is also useful to predict failed facemask ventilation.
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Journal of anesthesia · Jun 2020
The predictive performance of propofol target-controlled infusion during robotic-assisted laparoscopic prostatectomy with CO2 pneumoperitoneum in the head-down position.
Propofol clearance can be reduced when cardiac output (CO) is decreased. This clearance reduction may alter the pharmacokinetics of propofol and worsen the predictive performance of target-controlled infusion (TCI) of propofol. The head-down position (HDP) and CO2 pneumoperitoneum, which are required for robotic-assisted laparoscopic prostatectomy (RALP), may cause changes in CO. We investigated the predictive performance of propofol TCI during CO2 pneumoperitoneum in patients who underwent RALP in the HDP. ⋯ The predictive performance of propofol TCI during RALP with CO2 pneumoperitoneum in the HDP was acceptable.
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Journal of anesthesia · Jun 2020
Preoperative cognitive impairment associated with oversedation during recovery from anesthesia.
Our objective was to examine the association between preoperative cognitive status and postoperative recovery from anesthesia. ⋯ Cognitive impairment was associated with higher rates of moderate-deep residual sedation during anesthesia recovery and delirium, while moderate-deep sedation was associated with higher rates of pulmonary complications and delirium. We speculate that tailoring the anesthetic to facilitate faster emergence for CI patients could improve complication rates.
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Journal of anesthesia · Jun 2020
The effect of desflurane on retinal angiogenesis in a mouse model of oxygen-induced retinopathy.
Retinopathy of prematurity (ROP) is an ocular disorder that primarily occurs in premature infants and is the most common cause of vision impairment. This study examined the effect of desflurane on angiogenesis in a mouse model of oxygen-induced retinopathy (OIR). ⋯ Desflurane does not have a significant influence on retinal angiogenesis via HIF-1α and VEGF-A expression in the OIR mouse model. However, these findings are not directly applicable to premature infants, and it is thus necessary to perform further studies to determine the effect of desflurane on angiogenesis.
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Journal of anesthesia · Jun 2020
Stiripentol alleviates neuropathic pain in L5 spinal nerve-transected mice.
Antiepileptic drugs are used not only for the treatment of epilepsy but also for that of neuropathic pain. However, their action mechanisms have not always been well explained. Stiripentol, an effective antiepileptic drug indicated as a therapeutic for Dravet syndrome, was recently shown to act as an inhibitor of lactate dehydrogenase in astrocytes. In this present study, we examined the effect of stiripentol on neuropathic pain in L5 spinal nerve-transected mice. ⋯ This present study demonstrated that stiripentol was effective against neuropathic pain and suggested that the astrocyte-neuron lactate shuttle was involved in such pain.