Journal of anesthesia
-
Journal of anesthesia · Dec 1994
Capillary blood flow and arteriolovenular shunt in various organs in hypotensive states induced by nitroglycerine, nitroprusside, and nicardipine.
The capillary blood flow of 14 organs was measured in dogs using the microsphere (9μm diameter) trapping method under hypotension induced by administration of either nitroglycerin (NTG), nitroprusside (SNP), or nicardipine (NIC). Simultaneously, blood flow through the arteriolovenular shunt in the brain, kidney, liver, mesenteric organs, skeletal muscles of the pelvic limb, and all organs in the body, except the lungs, were measured by collecting venous blood drained from the organs at 4.8 ml·min-1 for 2 min. Capillary blood flow remained unchanged in most organs under hypotension with either NTG or SNP, but in increased in most organs, together with an increase in cardiac output, under hypotension with NIC. ⋯ However, arteriolovenular shunt remained unchanged under hypotension with SNP. Arteriolovenular shunt increased in the mesenteric organs under hypotension with NIC, but decreased in the skeletal muscles of the pelvic limb. These results indicated that none of these hypotensive drugs impairs the nutrient supply to organs; further, NIC protects it much more since it does not increase the shunt flow through major organs.
-
Journal of anesthesia · Dec 1994
Cutaneous distribution of sympathetic postganglionic fibers from stellate ganglion: A retrograde axonal tracing study using wheat germ agglutinin conjugated with horseradish peroxidase.
Sympathetic postganglionic cells of the stellate ganglion (SG) projecting to the skin in young dogs were labeled retrogradely with wheat germ agglutinin conjugated with horseradish peroxidase (WGA-HRP). After application of WGA-HRP into the dermis and/or subcutaneous tissue of the upper extremity, numerous labeled cells were observed in the SG. The sympathetic postganglionic fibers from the SG were distributed in the skin area between the third cervical vertebra and the level of the thirteenth rib. ⋯ The application was made in the cervical sympathetic trunk (CST) caudal to the superior cervical ganglion (SCG). In the thoracic sympathetic trunk (TST), the application was made between the fourth and fifth thoracic sympathetic ganglia (T4 and T5), and between T10 and T11. Labeled cell bodies were observed in SG bilaterally.