Journal of anesthesia
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Journal of anesthesia · Dec 1994
Attenuation of ischemia reperfusion-induced lung edema by prostaglandin I2 analogue OP-2507 in the isolated perfused rat lung.
Using the physiological salt solution (PSS)/Ficollperfused rat lung, we studied the effect of prostaglandin I2 (PGI2) analogue, OP-2507, on ischemia-reperfusion lung injury. Ischemia was induced by stopping perfusion and ventilation. ⋯ Lactate dehydrogenase release from the OP-2507-treated lungs of both doses were significantly lower than the untreated lungs. Thus, OP-2507 seems to be a useful agent for preventing ischemia-reperfusion lung injury.
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Journal of anesthesia · Dec 1994
Sore throat incidence with the laryngeal mask: A comparison with orotracheal intubation.
The incidence of sore throat was evaluated among 80 healthy (ASA 1 and 2) nonpremedicated adult patients undergoing general anesthesia for general, plastic, urologic, gynecologic, and orthopedic surgery. The patients were randomly allocated in two groups: group one (n=39) consisted of patients in whom the airway was maintained by a laryngeal mask, and in group 2 (n=40), orotracheal intubation was performed. ⋯ The severity of sore throat was graded by the patients themselves using a visual analogue 100 mm scale, varying from 0 (no sore throat) to 10 (extremely sore). The sore throat incidence, severity and duration were significantly lower in the laryngeal mask group in comparison with the endotracheal intubation group.
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Journal of anesthesia · Dec 1994
Cardiorespiratory dynamics during successful and unsuccessful trials of weaning from mechanical ventilation following cardiac surgery.
The purpose of this study was to examine the effects of a weaning trial with pressure support ventilation (PSV) on the cardiorespiratory dynamics in 20 cardiac surgery patients. In the patients who failed a weaning trial (failure group,n=6), the mean duration of cardiopulmonary bypass was 270±83 min and the mean postoperative lung-thorax compliance was 38±5 ml·cmH2O-1, whereas in successfully weaned patients (success group,n=14) they were 145±30 min and 55±10 ml·cm H2O-1 respectively (mean±SD). Significant differences were recognized in those values between the two groups. ⋯ Oxygen consumption ([Formula: see text]) increased and mixed venous O2 tension ([Formula: see text]) decreased in the failure group, whereas[Formula: see text] remained constant and[Formula: see text] increased in the success group. These data suggest that prolonged cardiopulmonary bypass might have produced acute lung injury. Decreased lung compliance may be responsible for rapid shallow breathing and an increase in oxygen consumption during a weaning trial, and may lead to weaning failure from mechanical ventilation.