Journal of anesthesia
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Journal of anesthesia · Jan 2009
Randomized Controlled TrialEffects of intravenous adenosine 5'-triphosphate on intraoperative hemodynamics and postoperative pain in patients undergoing major orofacial surgery: a double-blind placebo-controlled study.
We conducted a double-blind placebo-controlled study to investigate the effects of the intraoperative intravenous infusion of adenosine 5'-triphosphate (ATP) on intraoperative hemodynamics and postoperative pain in patients undergoing major orofacial surgery. ⋯ Our data suggest that intraoperative ATP infusion can blunt hemodynamic responses to surgical stimuli and produce prolonged analgesia in patients undergoing major orofacial surgery.
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Journal of anesthesia · Jan 2009
Randomized Controlled Trial Comparative StudyIsoflurane and sevoflurane decrease entropy indices more than halothane at equal MAC values.
Recently, bispectral index (BIS) values were demonstrated to be different for various anesthetics as a result of differential effects on electroencephalographic (EEG) signals. Entropy is similar to the BIS monitor, as both process raw EEG to derive a number. We hypothesized that entropy may also be anesthetic agent-specific. ⋯ During the study period, for a given MAC value, both RE and SE remained low in the isoflurane and sevoflurane groups compared to the halothane group. For a given MAC, the RE and SE were comparable during wash-in and wash-out phases. Halothane produced higher entropy values as compared to isoflurane and sevoflurane at equivalent MAC levels.
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Journal of anesthesia · Jan 2009
Randomized Controlled TrialPremedication with dexmedetomidine and midazolam attenuates agitation after electroconvulsive therapy.
This study was designed to compare the effects of premedication with dexmedetomidine and midazolam on post-electroconvulsive therapy (ECT) agitation (which patients had experienced previously and had been resistant to treatment). In addition, we aimed to evaluate the duration of convulsion, the propofol requirement, the recovery time, and patients' satisfaction during and after ECT. ⋯ Premedication with low-dose intravenous dexmedetomidine, 0.5 microg x kg(-1) or midazolam, 0.025 mg x kg(-1) before ECT may be useful in managing treatment-resistant agitation after ECT, without adverse effects.
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Journal of anesthesia · Jan 2009
Randomized Controlled Trial Comparative StudyHyperventilation versus standard ventilation for infants in postoperative care for congenital heart defects with pulmonary hypertension.
In infants undergoing surgery for cardiac defects with left-to-right shunt, a hyperventilation strategy has been applied to prevent pulmonary hypertensive crisis (PHC). Hyperventilation with a large tidal volume and/or higher airway pressure, however, may be detrimental to the lung. This randomized study compared the effects of hyperventilation versus standard ventilation. ⋯ Hyperventilation may cause lung injury and systemic inflammation in infants with pulmonary hypertension undergoing corrective heart surgery.
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Journal of anesthesia · Jan 2009
Randomized Controlled TrialA randomized study of the effects of perioperative i.v. lidocaine on hemodynamic and hormonal responses for cesarean section.
Intravenous infusion of lidocaine attenuates the stress response to surgery. We aimed to evaluate the effects of perioperative lidocaine on the hemodynamic and hormonal responses for cesarean delivery. ⋯ Perioperative lidocaine is safe and effective in attenuating the maternal stress response to surgery for cesarean delivery.