Der Schmerz
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Randomized Controlled Trial Comparative Study
[Effects of interdisciplinary functional restoration treatment with cognitive behavior therapy in patients with chronic back pain : Healthcare research in the context of selective contracts].
The efficacy of functional restoration programs for the treatment of chronic back pain is well documented. Nevertheless, there are only a few such centres in Germany and few trials have been conducted in German-speaking regions to demonstrate that implementing such programs in everyday clinical settings with large numbers of patients is just as effective as in a research setting. The present study examined whether the positive effects of such programs can also be observed in the clinically relevant context of a standardized day clinic treatment regimen. ⋯ In both cities significant and long-term improvements in back pain, pain-related impairment and degree of chronification were observed, as well as a high return-to-work rate after treatment. Hence, the quality of such programs was also confirmed for a large patient population.
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Randomized Controlled Trial
[Phantom limb pain. Psychological treatment strategies].
Similar to other pain syndromes phantom limb pain is characterized by learning and memory processes that maintain the pain and increase maladaptive plastic changes of the brain: therefore, psychological interventions that change maladaptive memory processes are useful. In addition to traditional psychological interventions, such as pain management training and biofeedback, more recent developments that involve sensory discrimination training, mirror treatment, graded motor imagery, prosthesis training and training in virtual reality are interesting. These interventions not only reduce phantom limb pain but also reverse the associated maladaptive brain changes.
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Randomized Controlled Trial Comparative Study
[Long-term effects of interventional treatment on chronic pain of the musculoskeletal system. Retrospective outcome study of repeated in-patient treatment].
Interventional procedures are frequently used for treatment of musculoskeletal pain syndromes but current scientific evidence does not show successful outcome in chronic cases. In this study the effect of repeated interventional treatment on the long-term outcome of patients with chronic musculoskeletal pain was examined. ⋯ Repeated treatment cycles of interventional pain therapy did not lead to an improvement in the treated pain syndromes and in the long term the pain syndromes deteriorated further. It seems likely that the interventional approach promoted this adverse development but the data of this study are not sufficient to conclusively prove this thesis.
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Randomized Controlled Trial Multicenter Study
[Botulinum toxin type A in the prophylactic treatment of chronic migraine].
Since the second edition of the International classification of headache disorders (ICDH-II 2004), chronic migraine has been listed amongst migraine complications. Compared to episodic migraine the prevalence of chronic migraine is low, its impact, however, significant. Until recently no prophylactic drug had been approved for chronic migraine prophylaxis. ⋯ Thus, for the first time a prophylactic drug against chronic migraine is available which is both effective and well tolerated. Botox® has been licensed in England for the prophylaxis of headaches in adults with chronic migraine in 2010. Approval for its use in Germany has been applied for.
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Randomized Controlled Trial Comparative Study
[Clonidine for remifentanil-induced hyperalgesia: a double-blind randomized, placebo-controlled study of clonidine under intra-operative use of remifentanil in elective surgery of the shoulder].
In the postoperative period, α2-adrenergic agonists have an opioid sparing effect. In a previous, experimental study, it was also shown that clonidine attenuates remifentanil-induced hyperalgesia. In this study, we examined under clinical conditions whether early administration of a single dose of clonidine can inhibit remifentanil-induced hyperalgesia in patients undergoing elective surgery of the shoulder and with continuous intraoperative use of remifentanil. ⋯ An early single dose of 150 µg of clonidine did not reduce the postoperative morphine consumption and pain scores in patients undergoing elective surgery of the shoulder with remifentanil/propofol-based anaesthesia. After the effect of clonidine has presumably subsided the pain can even increase, therefore further studies with repetitive doses of clonidine should be carried out.