Respiratory medicine
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Respiratory medicine · Oct 2009
Randomized Controlled Trial Multicenter StudyEvaluation of withdrawal of maintenance tiotropium in COPD.
In chronic diseases such as chronic obstructive pulmonary disease (COPD), patients may not perceive all of the benefits of drug therapy until withdrawal. Thus, we evaluated the effect of tiotropium withdrawal on clinical variables. ⋯ The withdrawal of tiotropium results in worsening of COPD over a three-week interval. There was no evidence of a rebound effect in response to tiotropium withdrawal.