Respiratory medicine
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Respiratory medicine · Oct 2010
Randomized Controlled Trial Multicenter StudyBudesonide added to formoterol contributes to improved exercise tolerance in patients with COPD.
Breathlessness and exercise intolerance frequently impact the daily life of patients with COPD. ⋯ Budesonide/formoterol resulted in a significant improvement in endurance time 1 h after the last morning dose in a 1-week treatment period versus formoterol and placebo. This study demonstrates, for the first time, the benefit of inhaled corticosteroids in addition to long-acting beta(2)-agonists on exercise tolerance in COPD patients. www.clinicaltrials.gov registration number: NCT00489853.
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Respiratory medicine · Oct 2010
Randomized Controlled Trial Multicenter StudyA one-year trial of tiotropium Respimat plus usual therapy in COPD patients.
In this randomised double-blind study, patients >or=40 years old with COPD, a smoking history of >or=10 pack-years, a pre-bronchodilator FEV(1) of