Respiratory medicine
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Respiratory medicine · Mar 2012
Randomized Controlled TrialEffect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations.
Recent studies have shown that neurogenic inflammation induced by cigarette smoke is inhibited by TRPA1 antagonist, but not by TRPV1 antagonist. Since cough reflex sensitivity is known to be modified by smoking status, we investigated the effects of cigarette smoking on TRPA1- and TRPV1-induced cough and urge-to-cough in healthy males. ⋯ The study suggests that smoking has a differential effect on cough responses between TRPV1 and TRPA1 stimulations.