Respiratory medicine
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Respiratory medicine · Feb 2014
Review Meta AnalysisNocturnal noninvasive positive pressure ventilation in stable COPD: a systematic review and individual patient data meta-analysis.
The effects of nocturnal noninvasive positive pressure ventilation (NIPPV) in patients with stable chronic obstructive pulmonary disease (COPD) remain controversial. ⋯ At present, there is insufficient evidence to support the application of routine NIPPV in patients with stable COPD. However, higher IPAP levels, better compliance and higher baseline PaCO2 seem to improve PaCO2.
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Respiratory medicine · Feb 2014
Meta AnalysisPooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD.
This post-hoc analysis examined the impact of roflumilast on chronic obstructive pulmonary disease (COPD) exacerbations and lung function in patients with COPD who received concomitant long-acting β2-agonists (LABA) with or without prior inhaled corticosteroid (ICS) and the influence of various demographic and clinical characteristics on these outcomes. ⋯ NCT00297102 (M2-124) and NCT00297115 (M2-125).