Respiratory medicine
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Respiratory medicine · Jul 2017
Randomized Controlled TrialEvaluation of the psychometric properties of the St George's Respiratory Questionnaire in patients with severe asthma.
Limited data exist on the quantitative validity of the St George's Respiratory Questionnaire (SGRQ) in asthma populations. This study evaluated the psychometric properties of the SGRQ in patients with severe asthma. ⋯ This analysis demonstrated that the SGRQ has acceptable psychometric properties in patients with severe asthma, exceeding the thresholds for adequate reliability, validity and responsiveness. The SGRQ appears to be a good instrument for identifying response to therapy in patients with severe asthma.
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Respiratory medicine · Jul 2017
Randomized Controlled TrialEffect of a single exacerbation on decline in lung function in COPD.
COPD exacerbations are associated with accelerated lung function decline, but whether they are causal is unknown. We evaluated the effect of a single exacerbation on rate of lung function change using data from the 4-year Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT®) trial. ⋯ A single COPD exacerbation may result in significant increase in the rate of decline in lung function.