Respiratory medicine

The most recent articles from: July 2019

  • Respiratory medicine · Jul 2019

    Review

    Monoclonal antibodies for severe asthma: Pharmacokinetic profiles.

    Several monoclonal antibodies (mAbs) (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) are currently approved for the treatment of severe asthma. They have complex pharmacokinetic profiles. ⋯ Their clearance is nonlinear because of the saturation of the target-mediated elimination. Also anti-drug antibody (ADA) response and off-target binding, as well as their glycosylation pattern, can influence the pharmacokinetics of mAbs.

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