Inhalation toxicology
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Inhalation toxicology · Apr 2013
Adenovirus-delivered angiopoietin-1 treatment for phosgene-induced acute lung injury.
Exposure to phosgene can result in an acute lung injury, leading to pulmonary edema and even death. Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization due to its ability to reduce endothelial permeability and inflammation. ⋯ Ang1 has the beneficial effects on phosgene-induced lung injury. The adenovirus-delivered Ang1 may have the potential as a novel approach for the treatment of the acute lung injury caused by phosgene gas inhalation in humans.