Inhalation toxicology
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Inhalation toxicology · Feb 2015
Randomized Controlled TrialCardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1.
Exposure to ozone has acute respiratory effects, but few human clinical studies have evaluated cardiovascular effects. ⋯ We did not find convincing evidence for early acute adverse cardiovascular consequences of ozone exposure in young healthy adults. The ozone-associated blunting of the blood pressure response to exercise is of unclear clinical significance.
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Inhalation toxicology · Jul 2008
Randomized Controlled TrialFurosemide inhalation in dyspnea of mustard gas-exposed patients: a triple-blind randomized study.
Dyspnea is the hallmark symptom of some respiratory diseases such as chronic obstructive pulmonary disease and bronchiolitis and is a major reason for which these patients seek medical attention. We performed a randomized triple-blind controlled crossover clinical trial in which we compared the efficacy of inhaled furosemide (4 ml equal to 40 mg in 10 min) with placebo (4 ml of 0.9% saline solution) in 41 mustard gas-exposed patients. ⋯ Our results failed to address the previously reported effects of inhaled furosemide on dyspnea. In fact, we suggest that patients with a previous exposure to sulfur mustard, in which chronic bronchitis and bronchiolitis are the most suggested underlying mechanisms, may not benefit from furosemide to alleviate their dyspnea.