Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Oct 2016
Randomized Controlled TrialPatient-controlled Analgesia With Propacetamol-Fentanyl Mixture for Prevention of Postoperative Nausea and Vomiting in High-risk Patients Undergoing Spine Surgery: A Randomized Controlled Trial.
This randomized trial evaluated the effect of intravenous patient-controlled analgesia (IV-PCA) based on fentanyl mixed with either propacetamol or an equivalent volume of normal saline on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing spinal surgery. ⋯ In patients undergoing spinal surgery and at risk of developing PONV, continuous IV-PCA based on propacetamol mixed to fentanyl, relative to fentanyl alone, effectively reduced the incidence of PONV, pain intensity at rest, and additional use of rescue analgesics with higher patient satisfaction.
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J Neurosurg Anesthesiol · Oct 2016
Noninvasive Measurement of Cerebral Blood Flow Under Anesthesia Using Arterial Spin Labeling MRI: A Pilot Study.
Cerebral ischemia plays a major role in pathophysiology of the injured brain. Most of the currently available methods of cerebral blood flow (CBF) monitors are either indirect measure of CBF or needing radioactive agents for data acquisition. Arterial spin labeling magnetic resonance imaging (ASL-MRI) is a noninvasive method of measuring CBF. The aim of our study was to determine the differences in the CBF values between propofol and sevoflurane anesthesia using ASL-MRI technique in mechanically ventilated patients with cerebrovascular disease. ⋯ ASL-MRI is a feasible, noninvasive method of quantitative estimation of global and regional CBF in mechanically ventilated patients under anesthesia. In this pilot study CBF was consistently greater with sevoflurane than with propofol.
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J Neurosurg Anesthesiol · Oct 2016
Use of Anesthesia for Imaging Studies and Interventional Procedures in Children.
Ongoing investigation from the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) study hopes to examine the long-term effect on cognitive and language development of a single anesthetic exposure in children undergoing inguinal hernia repair. The fifth PANDA Symposium, held in April 2016, continued the mission of previous symposia to examine evidence from basic science and clinical studies on potential neurotoxic effects of anesthetics on developing brain. At the 2016 Symposium, a panel of specialists from nonsurgical pediatric disciplines including anesthesiology, radiology, neurology, gastroenterology, oncology, cardiology, and critical care reviewed use of anesthesia in their practices, including how concern over possible neurodevelopmental effects of early childhood anesthetic exposure has changed discussion with patients and families regarding risks and benefits of imaging studies and interventional procedures involving sedation or anesthesia. This paper summarizes presentations from nonsurgical pediatric specialists at the 2016 PANDA Symposium.
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J Neurosurg Anesthesiol · Oct 2016
Remifentanil Requirement for Inhibiting Responses to Tracheal Intubation and Skin Incision is Reduced in Patients With Parkinson's Disease Undergoing Deep Brain Stimulator Implantation.
Parkinson's disease (PD) is a common neurodegenerative disease affecting the quality of life in the elderly. We speculated that PD patients might have abnormal pharmacodynamics due to the degenerative neural system, and the present study was performed to investigate the pharmacodynamics of remifentanil in PD patients. ⋯ The remifentanil concentrations required for inhibiting responses to tracheal intubation and skin incision are reduced markedly in PD patients undergoing pulse generator placement (NCT01992692).