Journal of neurosurgical anesthesiology
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J Neurosurg Anesthesiol · Jan 2012
Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats.
Opioid agonists have been implicated in neuroprotection from hypoxic injury through regulating mitogen-activated protein kinases and cytokines. We determined the effects of remifentanil in focal brain ischemia and reperfusion (I/R) injury. Mechanisms linked to mitogen-activated protein kinases, including extracellular signaling-regulated kinase (ERK) 1/2, p38 kinases, and c-Jun N-terminal kinase (JNK), and various cytokines were also examined. ⋯ Remifentanil may be neuroprotective against focal I/R injury, possibly through the activation of δ-opioid receptors and attenuation of ERK 1/2 activity and TNF-α production, in the rat brain.
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J Neurosurg Anesthesiol · Jan 2012
Letter Case ReportsBilateral Tapia syndrome secondary to oropharyngeal intubation.
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J Neurosurg Anesthesiol · Jan 2012
Letter Case ReportsAcute hemodynamic disturbances during lumbar spine surgery.
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J Neurosurg Anesthesiol · Jan 2012
Letter Case ReportsWater-electrolyte disturbances after pituitary surgery.