The Journal of neuropsychiatry and clinical neurosciences
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J Neuropsychiatry Clin Neurosci
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J Neuropsychiatry Clin Neurosci · Jan 2007
Review Meta AnalysisPsychopathology in verified Huntington's disease gene carriers.
Huntington's disease is characterized by motor, cognitive, and neuropsychiatric symptoms. This study reviews original research on psychopathology in Huntington's disease that uses standardized instruments in verified gene carriers. ⋯ Available research provides little insight into the true prevalences of psychopathology in Huntington's disease due to small sample sizes, use of different methodologies, and lack of comparison groups. Future research requires larger cohorts stratified to disease stage, consistent methodologies, and adequate comparison groups.