Burns : journal of the International Society for Burn Injuries
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Electrical injuries induce progressive tissue loss caused by free oxygen radicals released from neutrophil aggregates. Fucoidin, a potent inhibitor of L-selectin function, reduces the aggregation of neutrophils. The aim of this study was to evaluate the effect of fucoidin on tissue damage in rat electrical burn injury model. ⋯ Fucoidin inhibits tissue damage induced by electrical burn injury in rats by reducing necrotic area, edema and number of neutrophils.
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The Alfred pre-hospital fluid isotonic crystalloid resuscitation formula for major burns (body weight (kg)×%TBSA burnt=mls in the first 2 h) was adopted by Ambulance Victoria in 2007 for the early and consistent correction of fluid deficit in major burns patients. The aim of this study was to evaluate the associated change in pre-hospital fluid administration. ⋯ The Alfred pre-hospital fluid formula has resulted in patients receiving significantly more fluids early, although still below volumes suggested by the Parkland formula. There were no adverse effects of this increased volume detected over the study period. The Alfred pre-hospital fluid formula appears to be safe and more effective in delivering fluid volumes predicted by the current 'gold standard'.
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Case Reports
The use of non-contact structured light scanning in burns pressure splint construction.
This paper describes the use of a non-contact structured light scanning technique, computer aided design (CAD) and additive manufacturing (AM) to produce a burns pressure therapy splint, also known as mask or conformer. Masks such as this are used in the treatment of hypertrophic scars resulting from burns injuries. The case study described here is of a nine year old girl with significant hypertrophic scars to her face, especially her nasal bridge. ⋯ This data was then post processed and used to produce a model of the patients face using the three dimensional printing processes from Z Corporation. The plaster model formed was then used to generate a former on which a polyethylene tetrephthalate glycol (PETG) mask was vacuum formed. The results illustrate the benefits and effectiveness in terms of accuracy of adopting an integrated surface scanning, CAD and AM approach for easier intervention and treatment.
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We recently demonstrated that IL-18 injections following burn restored IFN-γ production and increased mouse survival after bacterial infection. However, it has yet to be fully elucidated how the IL-18 therapy affects the function of phagocytic cells. We investigated the effect of IL-18 therapy on function and interaction of Kupffer cells and NK cells in burned mice. ⋯ Consistently, IL-18 restored the impaired E. coli killing activity of Kupffer cells of burn-injured mice. Such Kupffer cell activation by IL-18 was abrogated by the deletion of NK cells or IFN-γ. In conclusion, IL-18 therapy in burn-injured mice enhanced function of CD68(+) Kupffer cells via the activation of liver NK cells and augmentation of their IFN-γ production, thereby improving survival after E. coli infection.