Burns : journal of the International Society for Burn Injuries
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To investigate coagulation disorders and thrombotic complications in the early stage after burn, and to evaluate the predictive reliability of D-dimer for deep vein thrombosis (DVT) diagnosis in major burn patients. ⋯ Early coagulation disorder can occur and last for over 28 days after major burn injury. The serum D-dimer level on the 7th post-burn day may be used as a risk factor to identify the individuals with high-risk of DVT among major burn patients.
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Keloid is a benign skin tumor that result from abnormal wound healing and excessive collagen deposition. The pathogenesis is believed to be linked to genetic predisposition and immune imbalance, although the precise mechanisms remain poorly understood. Current therapeutic approaches may not consistently yield satisfactory outcomes and are often accompanied by potential side effects and risks. The high recurrence rate and refractory nature of keloid nodules present significant challenges and uncertainties in their management. Given the lack of effective treatment strategies, it is essential to identify key molecular pathways and potential therapeutic targets for keloid. ⋯ DUSP1 and HOXA5 are hub genes in keloid pathogenesis, with DUSP1 acting as an inhibitor and HOXA5 as a promoter of disease progression. Targeting the regulatory networks associated with these genes could provide novel therapeutic strategies. Mast cells and macrophages are identified as critical immune cell types involved in the disease process. Additionally, the IL17 signaling pathway plays a crucial role in keloid development, highlighting its potential as a therapeutic target. These findings suggest that a multi-target approach focusing on these pathways could offer effective treatment options for keloid patients.
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Scalds account for 40 % of burn injuries in developed countries, with a subset occurring during caregiving activities, particularly when gloves are worn. Gloves, a standard precaution against infection and body fluid exposure, may impair sensory feedback critical for detecting temperature changes, potentially increasing the risk of burns during personal care tasks. ⋯ The findings underscore the heightened risk of scald injuries in vulnerable individuals due to delayed heat detection caused by gloves. Awareness of altered temperature thresholds during glove use is essential to prevent burns during caregiving tasks, particularly in activities requiring precise temperature assessment, such as bathing or showering. Enhanced education and preventive measures are crucial for ensuring safety in these contexts.