Allergologia et immunopathologia
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Allergol Immunopathol (Madr) · Mar 1996
Randomized Controlled Trial Comparative Study Clinical TrialTime course of methacholine induced bronchoconstriction during drugs and spontaneous resolution.
We examined the resolution of the bronchial spasm induced by methacholine after administration of a dose sufficient to provoke PD20 to study, in patients with bronchial asthma, how spontaneous resolution (as opposed to bronchodilator-induced resolution) takes place. According to a randomization criterion, the patients were divided into four groups: 1) resolution induced by salbutamol (S), 2) by ipratropium bromide (I), 3) after placebo (P) and 4) spontaneous resolution (R). ⋯ On the whole, this phenomenon shows that pharmacological treatment accelerates the process of spontaneous resolution of the bronchial spasm induced by methacholine which, in our experience, beings to show after 15 minutes, and that after 60 minutes, there are no statistically significant differences in the four groups. It is our opinion that closer examination of this phenomenon may provide greater knowledge of the mechanisms that come into play during the phase after stimulation of the muscarinic receptors and that reasonably involve the system to eliminate the muscarinic drug.
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Allergol Immunopathol (Madr) · Mar 1996
Comparative Study Clinical Trial Controlled Clinical TrialExercise-induced asthma prophylaxis in athletes using inhaled nedocromil sodium.
This open labelled, group comparative, cross over study, was carried out to analyze the efficacy of two dosages of Nedocromil sodium (NS) in the prophylaxis of Exercise Induced Asthma (EIA). 13 athletes (6 males, 7 females), aged: 12-38 years, were studied measuring their EIA by forced spirometries prior and at 1, 3, 5, 10, 15 and 30 minutes post treadmill test. Four mg of NS were administered via inhalation chamber 30 minutes prior to the second test; prior to the third one;: NS at a dose of 4 mg every 8 hours during four weeks plus 4 mg of NS 30 minutes before it. ⋯ Nedocromil sodium (4 mg prior to exercise) is effective for EIA prophylaxis. Although no significant differences exist between both dosages, a greater protection index is reached after NS sustained administration.