European journal of internal medicine
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Eur. J. Intern. Med. · Nov 2019
Multicenter Study3P association (3PAs): Pituitary adenoma and pheochromocytoma/paraganglioma. A heterogeneous clinical syndrome associated with different gene mutations.
Pituitary adenomas (PA) associated with pheochromocytomas/paragangliomas (Pheo/PGL), also known as "the three P association" or "3PAs" could be the results of coincidence, but new evidence supports a common pathogenic mechanism in some patients. Our aim is to report the clinical data, surgical outcome, genetic findings of a large case series and review the current knowledge on this topic. ⋯ We actively suggest considering the possibility of hereditary disease in all cases with 3PA and performing a complete genetic study.
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Eur. J. Intern. Med. · Nov 2019
Multicenter StudySystemic phenotype of sarcoidosis associated with radiological stages. Analysis of 1230 patients.
To analyze the association between Scadding radiological stages of sarcoidosis at diagnosis and the disease phenotype (epidemiology, clinical presentation and extrathoracic involvement) in one of the largest cohorts of patients with sarcoidosis reported from southern Europe. ⋯ The key determinant associated with a differentiated systemic phenotype of sarcoidosis at diagnosis was interstitial pulmonary involvement rather than the individual Scadding radiological stage.