European journal of internal medicine
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Eur. J. Intern. Med. · Jul 2020
Review Meta AnalysisAntithrombotic treatment in patients with atrial fibrillation undergoing coronary angioplasty: rational convincement and supporting evidence.
The management of antithrombotic therapy in patients undergoing percutaneous coronary intervention (PCI) with an indication for long-term oral anticoagulant therapy (OAT) is still a matter of debate. We aim to evaluate the safety and the efficacy of dual therapy (DT) compared to triple therapy (TT) in this clinical setting. ⋯ Our findings suggest that DT is safer than TT with regard to occurrence of major bleeding. DT with a direct oral anticoagulant plus clopidogrel at discharge could be effective in most patients, maintaining aspirin in periprocedural phase and as longer "tailored" treatment for patients at higher ischemic risk.
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Eur. J. Intern. Med. · Jul 2020
Meta AnalysisCoffee Consumption is Associated with a Decreased Risk of Incident Chronic Kidney Disease: A Systematic Review and Meta-analysis of Cohort Studies.
Recent studies have suggested a renal protective effect of coffee consumption against development of chronic kidney disease (CKD) although the results remain inconclusive. This systematic review and meta-analysis aimed to comprehensively investigate this association by summarizing all available data. ⋯ A total of 4 cohort studies comprising of 25,849 participants met the inclusion criteria and were analyzed in the meta-analysis. The meta-analysis found a significantly decreased risk of incident CKD among coffee-drinkers compared with non-drinkers with the pooled risk ratio of 0.87 (95% CI, 0.81-0.95; I2 of 57%). The funnel plot of this study was relatively symmetric and was not indicative of publication bias CONCLUSIONS: A significant association between coffee consumption and a lower risk of incident CKD was demonstrated in this study.