European journal of internal medicine
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Eur. J. Intern. Med. · Sep 2021
ReviewObesity as an adipose tissue dysfunction disease and a risk factor for infections - Covid-19 as a case study.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. ⋯ Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance.
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Eur. J. Intern. Med. · Sep 2021
Clinical significance of anti-Ro52 (TRIM21) antibodies in adult patients with connective tissue diseases.
Clinical significance of anti-Ro52 antibodies in connective tissue diseases (CTD) is controversial. Anti-Ro52 antibodies might be associated with a more severe CTD phenotype, especially interstitial lung disease (ILD). The aims of this study were to evaluate ILD prevalence and severity, the prevalence of micro- or macroangiopathy and CTD-associated cancers in CTD with anti-Ro52 antibodies. ⋯ We found that anti-Ro52 antibodies were independently associated with ILD in CTD patients irrespective of CTD type. Anti-Ro52 antibodies could be associated with severity and a more relapsing disease course in CTD patients.
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Eur. J. Intern. Med. · Sep 2021
Patient motivation to lose weight: Importance of healthcare professional support, goals and self-efficacy.
People with obesity (PwO) often struggle to achieve and maintain weight loss. This can perpetuate and/or be influenced by feelings of low motivation. This analysis from ACTION-IO data identified factors associated with PwO motivation to lose weight. ⋯ NCT03584191.