European journal of internal medicine
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Eur. J. Intern. Med. · Dec 2022
Meta AnalysisProton pump inhibitors and the risk of cardiovascular events and cardiovascular mortality: A systematic review and meta-analysis of observational studies.
Observational research has indicated that proton pump inhibitors (PPIs) might increase the long-term risk of cardiovascular events. This study evaluated the evidence from observational studies for an effect of PPI monotherapy on the risk of incident cardiovascular events and cardiovascular mortality. ⋯ It is questionable, whether PPI monotherapy constitutes a cardiovascular risk factor.