European journal of internal medicine
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Eur. J. Intern. Med. · Nov 2024
Multicenter Study Observational StudyEffectiveness Of Tocilizumab In Aortitis And Aneurysms Associated With Giant Cell Arteritis.
Aortitis in Giant Cell Arteritis (GCA-aortitis) is a frequent complication that may lead to aneurysms. Tocilizumab (TCZ) was approved in GCA, but the efficacy in GCA-aortitis and aneurysms has not been analyzed to date. Our aim was to assess the effectiveness and safety of TCZ in a wide series of GCA-aortitis and aneurysms. ⋯ In patients with GCA-aortitis treated with TCZ, a rapid and maintained clinical and analytical improvement was observed. However, there was an uncoupling between clinical and EULAR remission with imaging remission.