European journal of internal medicine
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Eur. J. Intern. Med. · Nov 2024
Meta AnalysisDoor-to-antibiotic time and mortality in patients with sepsis: Systematic review and meta-analysis.
To evaluate whether the timing of initial antibiotic administration in patients with sepsis in hospital affects mortality. ⋯ Our findings show an improvement in mortality in sepsis patients with early administration of antibiotics at <3 and <6 hrs. Thus, these results suggest that antibiotics should be administered within 3 hrs of sepsis recognition or ED arrival regardless of the presence or absence of shock.