European journal of internal medicine
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Eur. J. Intern. Med. · Jun 2024
Meta AnalysisImpact of early initiation of ezetimibe in patients with acute coronary syndrome: A systematic review and meta-analysis.
Scant data is available on the efficacy and safety of adding ezetimibe to high-intensity statin therapy for early and rapid reduction of low-density lipoprotein cholesterol (LDL-C) within 4-12 weeks of an acute-event in acute coronary syndrome (ACS). We undertook this meta-analysis to address this knowledge-gap. ⋯ Addition of ezetimibe to high-intensity statin therapy at the time of acute coronary syndrome (ACS) index event is associated with significantly better low density lipoprotein cholesterol and total cholesterol reduction at day-7, 1-month, 3-months and 1-year of follow-up, which translates into a significantly lower recurrent cardiovascular events (death from any cause, major ACS, non-fatal stroke, non-fatal myocardial infarction, and ischemic stroke) post an index event of ACS.
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Eur. J. Intern. Med. · Jun 2024
Meta Analysis Comparative StudyComparison of diagnostic spectrum between inflammation of unknown origin and fever of unknown origin: A systematic review and meta-analysis.
Patients with inflammation of unknown origin (IUO) and fever of unknown origin (FUO) are commonly considered a single population. Differences in underlying causes between both groups may steer the diagnostic work-up. ⋯ Based on our findings, there is little reason to assume that FUO and IUO patients would benefit from a different initial diagnostic approach.