European journal of internal medicine
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Eur. J. Intern. Med. · Jan 2025
The impact of hypoalbuminemia on the long-term prognosis of patients with acute heart failure: The modifying role of carbohydrate antigen 125.
Hypoalbuminemia is frequently found in patients with heart failure (HF), associated with higher morbimortality in acute HF (AHF). Moreover, Carbohydrate Antigen 125 (CA125) is elevated in most of the AHF patients. In this cohort of patients admitted for AHF, our objective was to evaluate the association between hypoalbuminemia and long-term outcomes, including mortality and HF readmissions, stratified by CA125 concentration. ⋯ In patients with AHF, the prognostic impact of albumin is influenced by CA125 levels. Hypoalbuminemia was associated with higher risk of death or HF readmission only when coexisted with high CA125. On the contrary, when CA125 was low, hypoalbuminemia lacked prognostic effect.