European journal of internal medicine
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Eur. J. Intern. Med. · Sep 2016
Multicenter Study Comparative StudyVitamin K and non-vitamin K antagonist oral anticoagulants for non-valvular atrial fibrillation in real-life.
Current guidelines recommend vitamin K antagonists (VKAs) or non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in patients with non-valvular atrial fibrillation (AF). ⋯ Patients given rivaroxaban and apixaban in clinical practice have a higher thrombotic and hemorrhagic risk in comparison with patients given dabigatran or VKAs. A considerable proportion of patients receive reduced doses of NOACs.
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Eur. J. Intern. Med. · May 2016
Randomized Controlled Trial Multicenter Study Observational StudyPrior thromboprophylaxis and outcome in patients experiencing acute venous thromboembolism after an acute medical illness.
Even despite the use of thromboprophylaxis, some patients with an acute medical illness develop symptomatic venous thromboembolism (VTE). It is unclear whether the outcome in these patients is different in those in whom prophylaxis was not prescribed. ⋯ The outcome in patients with VTE provoked by medical immobilization was not influenced by the use of thromboprophylaxis during the period of immobility.
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Eur. J. Intern. Med. · Sep 2015
Multicenter StudyVenous thromboembolism and preoperative steroid use: analysis of the NSQIP database to evaluate risk in surgical patients.
Despite several prophylactic strategies, postoperative venous thromboembolism (VTE) remains a major cause of morbidity and mortality. Therefore, the search for modifiable preoperative risk factors is crucial. Few reports have explored this issue but the direct relationship between preoperative steroid use and postoperative VTE in surgical patients remains unexplored. ⋯ Our results suggest that surgical patients with prolonged preoperative glucocorticoid intake are at a higher risk of developing postoperative VTE as well as other secondary outcomes including: all-cause mortality, urinary tract occurrences, sepsis, wound occurrences, cardiac and respiratory adverse events. These are important findings since preoperative glucocorticoid use is a modifiable factor.
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Eur. J. Intern. Med. · Oct 2014
Multicenter Study Comparative Study Observational StudyInappropriate prescribing to older patients admitted to hospital: a comparison of different tools of misprescribing and underprescribing.
This study aims to assess inappropriate prescribing (IP) to elderly patients during the month prior to hospitalization and to compare different IP criteria. ⋯ A high prevalence of polypharmacy and PIMs and PPOs were reported. More than half the patients had simultaneous PIMs and PPOs. The related factors to PIMs and PPOs were different.
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Eur. J. Intern. Med. · Oct 2014
Multicenter StudyManaging ambulatory ulcerative colitis patients with infliximab: a long term follow-up study in primary gastroenterology centers.
Infliximab (IFX) is the key treatment for ulcerative colitis (UC) unresponsive to standard treatments. The aim of the present study was to assess the efficacy and safety of IFX in treating ambulatory UC patients in primary gastroenterology centers. ⋯ IFX seems to be effective and safe in long-term treatment of outpatients affected by UC.