The British journal of general practice : the journal of the Royal College of General Practitioners
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Randomized Controlled Trial Comparative Study
Effectiveness of diclofenac versus paracetamol in knee osteoarthritis: a randomised controlled trial in primary care.
The effectiveness of diclofenac versus paracetamol in primary care patients with pain caused by knee osteoarthritis is unclear. ⋯ Over a period of 2- and 4-weeks follow-up no significant difference in daily measured knee pain severity was found between primary care patients with knee osteoarthritis taking paracetamol or diclofenac. Also, over a period of 12-weeks follow-up no significant differences were found regarding KOOS pain and KOOS function between both groups. Patients more frequently reported minor adverse events after taking diclofenac (64%) than paracetamol (46%).