Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialConditions to optimise the reversal action of neostigmine upon a vecuronium-induced neuromuscular block.
Since neostigmine was introduced for reversal of neuromuscular block, there has been controversy about the optimum dose for antagonizing neuromuscular block. The purpose of this study was to characterise recovery of neuromuscular transmission following a vecuronium-induced block 15 min after neostigmine administration using different stimulation patterns, and to determine the effects of different doses of neostigmine given at various pre-reversal twitch heights. ⋯ To optimise the reversal action of neostigmine in order to obtain the highest neuromuscular transmission recovery (0.9 TOF ratio and RF100Hz) during a vecuronium-induced neuromuscular block, the 40 micrograms/kg dose has to be given at 25 to 50% recovery of TH.
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Acta Anaesthesiol Scand · May 1996
Results of in vitro contracture testing of both parents of malignant hyperthermia susceptible probands.
Malignant Hyperthermia (MH) is regarded as a dominantly inherited condition. Therefore, most investigators do not test the second parent if the first parent is found to be MH susceptible (MHS). The purpose of this study was to validate this policy. ⋯ We conclude that both parents should be tested whenever possible. For genetic research it is important that labelling any parent "presumed normal" may give misleading results.
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Acta Anaesthesiol Scand · May 1996
Sodium nitroprusside after cardiac surgery: systemic and splanchnic blood flow and oxygen transport.
Vasoactive drugs may interfere with splanchnic blood flow and tissue oxygenation. Sodium nitroprusside (SNP) is widely used in the treatment of postoperative hypertension after cardiac surgery, but the effects of SNP and other vasodilators on splanchnic blood flow have not been well documented. ⋯ These results suggest that vasoregulation is well preserved during treatment of early postoperative hypertension with SNP, and that SNP has no adverse effects on splanchnic tissue oxygenation.
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Acta Anaesthesiol Scand · May 1996
Case ReportsTransfusion-related acute lung injury (TRALI) after fresh frozen plasma in a patient with coagulopathy.
Transfusion-related acute long injury (TRALI) is due to specific antigen-antibody reaction involving the donor's leucocyte or granulocyte antibodies towards the recipient's antigens. Aggregation in small pulmonary vessels occurs, leading to derangement of permeability. ⋯ When TRALI is suspected the donor blood has to be tested against the recipient. Ventilatory support of the patient is continued until adequate oxygenation is reached.
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Comparative Study Clinical TrialNo additional analgesic effect of intra-articular morphine or bupivacaine compared with placebo after elective knee arthroscopy.
Intra-articular pain prophylaxis is a controversial measure, adding costs although the benefits are still disputed. We wanted to evaluate the effects of intra-articular opioid or local anaesthesia or a combination of the two on postoperative analgesia and analgesic consumption after elective knee arthroscopy. ⋯ Intra-articular administration of morphine or bupivacaine is not indicated after elective knee-arthroscopy in patients with minor pre-operative pain and a small surgical trauma.