Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Mar 1997
Alleviation of the peripheral hemodynamic effects of dexmedetomidine by the calcium channel blocker isradipine.
Alpha 2-adrenergic agonists have peripheral vasoconstrictive effects and central sympatholytic and sedative effects. Whereas the latter are the basis of their use in anesthesia, the former could limit their clinical application. ⋯ Isradipine could alleviate the peripheral hemodynamic actions of dexmedetomidine while having no effect on its central sympatholytic properties.