Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Oct 2000
Randomized Controlled Trial Clinical TrialEfficacy of intrathecal neostigmine for the relief of postinguinal hemiorrhaphy pain.
Intrathecal administration of various doses of neostigmine has been reported to produce analgesia without neurotoxicity in both animal and human studies. The present study was undertaken to evaluate the efficacy and safety of intrathecal neostigmine for the relief of pain for patients having undergone inguinal herniorrhaphy surgery. ⋯ Our study showed that intrathecal neostigmine at 50 pg or 100 microg enhanced the onset of tetracaine anaesthesia and provided analgesia lasting for 6-9 h, although increased incidences of prolonged motor blockade and nausea or vomiting were noted.
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Acta Anaesthesiol Scand · Oct 2000
Randomized Controlled Trial Clinical TrialPreoperative ropivacaine infiltration in breast surgery.
The aim of the study was to investigate whether preoperative infiltration with ropivacaine in conjunction with breast surgery improves postoperative pain management and attenuates postoperative nausea and vomiting. ⋯ We found no differences in postoperative pain management between 3.75 mg/ml ropivacaine and saline wound infiltration before breast surgery. The data show similar postoperative needs of analgesics and antiemetics with a similar frequency of PONV.
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Acta Anaesthesiol Scand · Oct 2000
Randomized Controlled Trial Clinical TrialElectrical stimulation of the vestibular system prevents postoperative nausea and vomiting.
Electrical stimulation of the vestibular system may prevent nausea and vomiting. We studied the influence of transcutaneous impulse stimulation in prevention of postoperative nausea and vomiting (PONV) following gynaecological surgery. ⋯ This study suggests that electrical stimulation of the vestibular system may be useful in prevention of PONV.
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Acta Anaesthesiol Scand · Oct 2000
Clinical TrialMixed venous oxygen saturation during mobilization after cardiac surgery: are reflectance oximetry catheters reliable?
Oximetry catheters immediately reflect changes in mixed venous oxygen saturation (SvO2). We have used the Baxter 2-SAT system to register changes in SvO2 during early mobilizations after cardiac surgery. To assess catheter reliability, readings were compared to blood gases. ⋯ The two methods are interchangeable for most clinical purposes. Catheter readings are, however, substantially lower than the corresponding haemoximetric measurements at low SvO2 values. Careful interpretation of the absolute values resulting from catheter measurements is recommended, especially when SvO2 readings are low.
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Acta Anaesthesiol Scand · Oct 2000
Clinical TrialBispectral index, predicted and measured drug levels of target-controlled infusions of remifentanil and propofol during laparoscopic cholecystectomy and emergence.
Target-controlled infusions (TCI) have been launched as simple, accurate and reliable delivery systems of intravenous drugs. Bispectral index of EEG (BIS) seems promising in measuring hypnotic effect of anaesthetic drugs. The aims of this study were to evaluate the accuracy of TCI systems in patients undergoing laparoscopic cholecystectomy and to correlate measured drug levels to BIS values. Data were analysed for possible gender differences during emergence. ⋯ Present systems for TCI of remifentanil and propofol result in large intra- and interindividual variations in measured drug levels, and measured levels differ from target. There may be possible interaction between the two anaesthetics at a pharmacokinetic level. Within the level of anaesthesia studied here, BIS was not an indicator of the actual drug levels. Women woke up significantly faster than men.