Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Aug 2003
Case ReportsLow utilisation of unactivated protein C in a patient with meningococcal septic shock and disseminated intravascular coagulation.
Activated protein C has recently been shown in a multicentre trial to significantly reduce mortality in patients with septic shock. There are also some case reports and minor studies demonstrating promising results with the unactivated form of protein C. However, in children with severe meningococcal infection, skin biopsies have demonstrated low expression of endothelial thrombomodulin and protein C receptors, suggesting low protein C activation capacity in severe meningococcal sepsis. ⋯ The result indicates that whole body utilisation of the unactivated protein C was low. Endothelial impairment of protein C activation does not seem to be restricted to the skin vessels only.
-
The laryngeal tube has a potential role during anaesthesia, but there have been only a few studies assessing its efficacy during the entire course of anaesthesia, and all previous studies used prototypes. We studied 100 patients to assess the efficacy of a new laryngeal tube during the entire course of anaesthesia. ⋯ The laryngeal tube can be useful for maintaining a patent airway during anaesthesia.