Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jul 2003
Citation classics in anaesthesia and pain journals: a literature review in the era of the internet.
The number of citations an article receives reflects its scientific impact. The introduction of internet-based resources to search and access articles has made it possible to review even whole scientific areas. This study identifies the top 50 most-cited articles over the last 25 years in specialty journals dedicated to anaesthesia and pain, respectively. ⋯ To make an article a possible 'citation classic' in anaesthesiology, it should be published in one of six leading journals and originate from an established institute in North America. Internet resources to publish and cite the literature have to date not advanced any article published in the last 5 years to the top 100 list.
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Acta Anaesthesiol Scand · Sep 2003
Tramadol encapsulated into polyhydroxybutyrate microspheres: in vitro release and epidural analgesic effect in rats.
Controlled release techniques are used to increase the duration of action and decrease the toxicity of drugs. Any controlled release form of tramadol in spinal or epidural blocks has not been studied previously. Tramadol was encapsulated into polyhydroxybutyrate (PHB) microspheres and release kinetics was studied. The epidural analgesic effect of this solution in rats was also compared with free tramadol. ⋯ Controlled release of tramadol from PHB microspheres is possible, and pain relief during epidural analgesia is prolonged by this drug formulation compared with free tramadol.
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Acta Anaesthesiol Scand · Jan 2003
Effects of acute normovolemic hemodilution on ventriculoarterial coupling in dogs.
Acute normovolemic hemodilution (ANH) causes a decrease in systemic vascular resistance. Similar to vasodilating drugs, ANH might modify ventriculoarterial coupling. Left ventricular elastance (Ees), effective arterial elastance (Ea), stroke work (SW), and pressure volume area (PVA) were used as indicators to examine the effects of ANH on this coupling. ⋯ Before ANH, ventriculoarterial coupling was so matched as to maximize SW at the expense of the work efficiency. This relation was preserved at ANH50.